Christine Lee Shrock
Christine Lee Shrock, 17, of Setauket, built computer models to carry out molecular dynamics simulations in studying the protein MDM2 and its effect on tumor suppression for her Intel Science Talent Search project in bioinformatics and genomics. She specifically focused on MDM2's effect on p53, an important tumor-suppressing protein. When it is bound to MDM2, p53 is inactivated, and a crucial part of the binding process is a segment of amino acid residues on MDM2 that forms a "lid." Through her computer simulation, Christine showed that when p53 is bound, the lid stays open; when the lid is closed, p53 is free to perform its tumor-suppressing function. She believes her results identify the lid opening mechanism as a target for a new class of cancer drugs. Christine is on the Principal’s Student Advisory Council at Ward Melville High School in East Setauket, where she performs with the chamber orchestra as soloist and concertmaster. She is an award-winning violinist who has been studying at the Juilliard Pre-College since 2002 and has performed at Carnegie Hall. Christine is first author of a manuscript being submitted for publication in Protein Science, and hopes to attend Harvard or Princeton. She is the daughter of Robert Shrock and I-Hsiu Lee.